Topic outline

  • Cancer therapy

    Today, cancer therapy is based primarily on chemotherapy and radiation, both of which have well-established side effects. Chemotherapy drugs typically kill not only cancer cells but also normal cells, and administration of bolus doses of these strong drugs can result in unpredictable side effects. One way of generating effective molecular probes to differentiate diseased cells is to use aptamers, that are capable of identifying molecular level differences between a healthy cell and a diseased cell

  • Thrombin Binding Aptamers

    Thrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I